Endocrine Abstracts

Introduction: Thyroid dysfunction is relatively common in amiodarone treated subjects, partly because of its high iodine content. The benefits of surveillance, early identification and management of such thyroid dysfunction have been established. We undertook a retrospective case notes audit of all amiodarone treated subjects in our hospital to evaluate thyroid surveillance and outcome.Methods: All patients treated with amiodarone between 2001 and 2004 w...

Case history: A 49-year-old male with hypertension (on doxazosin, amlodipine and perindopril), obesity (BMI 40 kg/m2) and recent DVT (on warfarin) presented with a few months’ history of episodic headaches, palpitations, light-headedness and sweats accompanied by facial pallor, occurring around twice weekly without warning. Symptoms were often worse when upright. Spontaneous recovery followed. He did not have a family history of endocrine disease. Clinical exam...

We report 2 patients with Graves’ thyrotoxicosis complicated by jaundice.Case 1 - A 36 year old referred to the gastroenterologists with a 3-month history of general malaise, myalgia, jaundice, 4 stone weight loss and diarrhoea. A hepatitis and autoimmune liver screen were negative, bilirubin elevated at 200 umol/l, coagulation screen and ultrasound scan were normal and a liver biopsy showed cholestasis. Thyroid function tests (TFT’s) demonstra...

An asymptomatic 66-year-old man was referred for investigation of chronic hypernatraemia. Plasma sodium varied between 146–152 mmol/l and potassium was normal over several years. There was no relevant past, family or drug history. There were no symptoms or signs of hypercotisolism or other endocrinopathy either. Clinical examination was normal.Initial investigations were as follows – sodium 149 mmol/l, potassium 4.3 mmol/l, urea 7.9 mmol/l, cre...